“This work, showing that distinct regions of the blastula-stage embryo are fated toward developing the neural crest, provides exciting new insight into the formation of this unique embryonic stem cell population,” said Maneeshi Prasad, a senior member of the Garcia-Castro lab, who played a critical role in the research and is a co-first author of the study. When neural crest biology fails, various birth defects and illnesses can result, such as cleft lip or palate, Waardenburg syndrome, and melanoma. The proper functioning of neural stem cells is critical for human development and health. Study results appear in Developmental Biology. The work proposes that neural crest precursors are endowed with a limited differentiation potential that is, nonetheless, broader than the potentials of the ectoderm or mesoderm. In other words, the neural crest emerges not from the ectoderm, but before, from the epiblast, a pluripotent cell stage,” Garcia-Castro said. The initiation of this path is evident prior to the appearance of a definitive ectoderm or mesoderm and arises before, and independently from, these two tissues. “These cells have already initiated the developmental path to form neural crest cells. The epiblast is the tissue from which later in development the three germ layers are formed: the endoderm, mesoderm, and ectoderm. “We were able to identify prospective neural crest cells in the epiblast of the chick blastula embryo,” Garcia-Castro said. Saving Earth Britannica Presents Earth’s To-Do List for the 21st Century.Martin Garcia-Castro is an associate professor of biomedical sciences at UC Riverside.Britannica Beyond We’ve created a new place where questions are at the center of learning.100 Women Britannica celebrates the centennial of the Nineteenth Amendment, highlighting suffragists and history-making politicians.COVID-19 Portal While this global health crisis continues to evolve, it can be useful to look to past pandemics to better understand how to respond today.Student Portal Britannica is the ultimate student resource for key school subjects like history, government, literature, and more.Britannica Explains In these videos, Britannica explains a variety of topics and answers frequently asked questions.Demystified Videos In Demystified, Britannica has all the answers to your burning questions.This Time in History In these videos, find out what happened this month (or any month!) in history.#WTFact Videos In #WTFact Britannica shares some of the most bizarre facts we can find.Britannica Classics Check out these retro videos from Encyclopedia Britannica’s archives.
0 kommentar(er)
